Event-related desynchronization, as a proxy for mirror neuron activity, has been used as a neurophysiological marker for motor execution after mirror visual feedback. Using EEG, this study investigated ERD upon the immediate effects of single-session MVF in unimanual arm movements compared with the ERD effects occurring without a mirror, in two groups: stroke patients with left hemiplegia and their healthy counterparts. During EEG recordings, each group performed one session of mirror therapy training in three task conditions: with a mirror, with (...) no mirror, and with a covered mirror. An asymmetry index was calculated from the subtraction of the event-related spectrum perturbations between the C3 and C4 electrodes located over the sensorimotor cortices contralateral and ipsilateral to the moved arm. Results of the effect of task versus group in contralateral and ipsilateral motor areas showed that there was a significant effect of task condition at the contralateral motor area in the high beta band at C3. High beta ERD showed that the suppression was greater over the contralateral hemisphere than it was over the ipsilateral hemisphere in both study groups. The magnitude of low beta ERD in patients with stroke was more suppressed in contralesional C3 under the no mirror compared to that of the covered mirror and similarly more suppressed in ipsilesional C4 ERD under the no mirror compared to that of the mirror condition. The correlation analysis revealed that the magnitude of ERSP power correlated significantly with arm severity in the low and high beta bands in patients with stroke, and a higher asymmetry index in the low beta band was associated with higher arm functioning under the no-mirror condition. There was a shift in sensorimotor ERD toward the contralateral hemisphere as induced by MVF accompanying unimanual movement in both stroke patients and healthy controls. The use of ERD in the low beta band as a neurophysiological marker to indicate the relationships between the amount of MVF-induced ERD attenuation and motor severity, and the outcome indicator for improving stroke patients’ neuroplasticity in clinical trials using MVF are warranted to be explored in the future. (shrink)

Up till now, China has not enacted any legal mechanisms governing certification or supervision for ethics committees. This article analyses deficiencies in the protection of subjects in clinical drug trials under China’s current laws and regulations; it emphasizes that investigators, as practitioners who have direct contact with subjects, play significant roles in protecting and safeguarding subjects’ rights and interests. The paper compares the status quo in China in this area to that of other countries and discusses ways China might enhance (...) the protection of rights and interests of trial subjects, such as enhancing the ethical awareness of investigators through training, improving laws and regulations, and strengthening the communication between investigators and ethics committees. (shrink)

We applaud Ray and Cooper (2024) for emphasizing environmental health as a bioethics issue. As a team of interdisciplinary pediatric researchers and providers who are part of an institutional clima...

Previous studies have identified the critical role of the left fusiform cortex in visual word form processing, learning, and memory. However, this so-called visual word form area's other functions are not clear. In this study, we used fMRI and the subsequent memory paradigm to examine whether the putative VWFA was involved in the processing and successful memory encoding of faces as well as words. Twenty-two native Chinese speakers were recruited to memorize the visual forms of faces and Chinese words. Episodic (...) memory for the studied material was tested 3. h after the scan with a recognition test. The fusiform face area and the VWFA were functionally defined using separate localizer tasks. We found that, both within and across subjects, stronger activity in the VWFA was associated with better recognition memory of both words and faces. Furthermore, activation in the VWFA did not differ significantly during the encoding of faces and words. Our results revealed the important role of the so-called VWFA in face processing and memory and supported the view that the left mid-fusiform cortex plays a general role in the successful processing and memory of different types of visual objects. © 2010 Elsevier Inc. (shrink)

If F ⊆ NN is an analytic family of pairwise eventually different functions then the following strong maximality condition fails: For any countable H ⊆ NN. no member of which is covered by finitely many functions from F, there is f ∈ F such that for all h ∈ H there are infinitely many integers k such that f(k) = h(k). However if V = L then there exists a coanalytic family of pairwise eventually different functions satisfying this strong maximality (...) condition. (shrink)

What is the nature of truth? This question has been answered by philosophers in quite different ways, while F. H. Bradley asserts that truths have degrees and that no proposition can be stated to be simply true or false. In this paper, I briefly illustrate what he calls the doctrine of degrees of truth and try to address the problems it entails. I first explain what he means by truth and error/falsehood (he does not make a clear distinction between the (...) two terms); then, I concentrate on his criticisms of three theories of truth, followed by a discussion of his own identity theory of truth. I will be focusing on his doctrine of the degrees of truth and highlight its difficulties. I show that his theory faces some insurmountable difficulties, and it should be motivated by a particular form of monism that he insisted on, saying existence monism. (shrink)

The starting-point of Plutarch's dialogue de communibus notitiis is a claim made by the Stoics that Providence sent Chrysippus to remove the confusion surrounding the ideas of ννοια and πρληψισ before the subtleties of Carneades were brought into play. Unfortunately our surviving information on the subject is so much less full than could be desired that it has again returned to an obscurity from which there are only two really detailed modern attempts to remove it. The one, by L. Stein (...) , is most unsatisfactory; the other, by A. Bonhöffer , though of the greatest value in many ways, is vitiated by the fact that it constructs a system from the use of the words by Epictetus and then attempts to attach this system to the old Stoa in the face of the evidence of the doxographers, which is emended or violently interpreted to suit Epictetus. Even if Epictetus were in general a good authority for the technicalities of Chrysippus—and in the opinion of H. von Arnim he is not— this would not be a sound method of procedure. The only safe way is to take first the statements which can be attached to the Old Stoa, and having obtained our results from these, to see whether Epictetus does in fact agree. (shrink)

This work combines two early pamphlets by F. H. Bradley, the foremost philosopher of the British Idealist movement. The first essay, published in 1874, deals with the nature of professional history, and foreshadows some of Bradley's later ideas in metaphysics. He argues that history cannot be subjected to scientific scrutiny because it is not directly available to the senses, meaning that all history writing is inevitably subjective. Though not widely discussed at the time of publication, the pamphlet was influential on (...) historian and philosopher R. G. Collingwood. The second pamphlet is Bradley's critique of Henry Sidgwick's The Methods of Ethics. Sidgwick was the first to propose the paradox of hedonism, which is the idea in ethics that pleasure can only be acquired indirectly. Published in 1877, this work is divided into three parts, treating Sidgwick's definitions, arguments, and his view of ethical science. (shrink)

Ballard and Zhang offer a fascinating review of how computational models of human vision have evolved since David Marr proposed his Tri‐Level Hypothesis, with a focus on the refinement of algorithm descriptions over time.

F. H. Bradley was the foremost philosopher of the British Idealist school, which came to prominence in the second half of the nineteenth century and remained influential into the first half of the twentieth. Bradley, who was influenced by Hegel and also reacted against utilitarianism, was recognised during his lifetime as one of the greatest intellectuals of his generation, and was the first philosopher to receive the Order of Merit, in 1924. In this major work, originally published in 1883, Bradley (...) discusses the basic principles of logic: judgment and inference. He rejects the idea of a separation between mind and body, arguing that human thought cannot be separated from its worldly context. In the second edition, published in 1922 and reissued here, Bradley added a commentary and essays, but left the text largely unaltered. Volume 1 contains Book 1 on judgment and Book 2 on inference. (shrink)

The five chapters which Quintilian has devoted to ‘Grammatica’ are in many ways the most valuable discussion of the subject which we possess. They are older than any other surviving account, except the remains of Varro De lingua Latino, and the grammar of Dionysius Thrax, and this last, though far more complete than Quintilian in its examination of the parts of speech, has nothing that compares with the other chapters on analogy, etymology, etc., nor does it give so clear a (...) view of ‘grammatica’ as a whole. These chapters do not appear to have been treated by any scholar since Nettleship published his article on ‘Latin Grammar in the First Century’ in the Journal of Philology, vol. xv. If, in the course of this paper, I traverse on certain points the opinions of so distinguished a scholar, let it be understood that I do so with much diffidence, and only after much consideration of the facts as they appear to me. (shrink)

The passage here discussed, VIII. 6. 33, occurs in one of the lacunas, and we are thus deprived of the help of the great mutilated MSS., and have to fall back upon A. and G. (the scribe who in the eleventh century filled up the lacunas in the mutilated Bambergensis. In § 31 Quintilian, in the course of his treatment of tropes, has reached onomatopoeia, and in § 32 that subdivision of the last-named, or perhaps we should say the kindred (...) subject, which he calls πεποιημένα This was as follows: uix ilia quae πεποιημένα uocant quae ex uocibus in usum receptis quocumque modo declinantur, nobis permittimus, qualia sunt ‘sullaturit’ et ‘proscripturit,’ atque ‘laureati postes’ pro illo ‘lauru coronati’ ex eadem fictione sunt. Sed hoc feliciter eualuit. (shrink)

Laughter as superiority -- The elements of laughter -- The one necessary thing -- Objections to the normative thesis -- Comic virtues and vices -- The social virtues -- The charismatic virtues -- Machine law -- Machine scholarship -- Machine art and machine cities -- The battle of the norms -- Resistance to laughter -- The sociability thesis -- Conclusion.