Event-related desynchronization, as a proxy for mirror neuron activity, has been used as a neurophysiological marker for motor execution after mirror visual feedback. Using EEG, this study investigated ERD upon the immediate effects of single-session MVF in unimanual arm movements compared with the ERD effects occurring without a mirror, in two groups: stroke patients with left hemiplegia and their healthy counterparts. During EEG recordings, each group performed one session of mirror therapy training in three task conditions: with a mirror, with (...) no mirror, and with a covered mirror. An asymmetry index was calculated from the subtraction of the event-related spectrum perturbations between the C3 and C4 electrodes located over the sensorimotor cortices contralateral and ipsilateral to the moved arm. Results of the effect of task versus group in contralateral and ipsilateral motor areas showed that there was a significant effect of task condition at the contralateral motor area in the high beta band at C3. High beta ERD showed that the suppression was greater over the contralateral hemisphere than it was over the ipsilateral hemisphere in both study groups. The magnitude of low beta ERD in patients with stroke was more suppressed in contralesional C3 under the no mirror compared to that of the covered mirror and similarly more suppressed in ipsilesional C4 ERD under the no mirror compared to that of the mirror condition. The correlation analysis revealed that the magnitude of ERSP power correlated significantly with arm severity in the low and high beta bands in patients with stroke, and a higher asymmetry index in the low beta band was associated with higher arm functioning under the no-mirror condition. There was a shift in sensorimotor ERD toward the contralateral hemisphere as induced by MVF accompanying unimanual movement in both stroke patients and healthy controls. The use of ERD in the low beta band as a neurophysiological marker to indicate the relationships between the amount of MVF-induced ERD attenuation and motor severity, and the outcome indicator for improving stroke patients’ neuroplasticity in clinical trials using MVF are warranted to be explored in the future. (shrink)

Up till now, China has not enacted any legal mechanisms governing certification or supervision for ethics committees. This article analyses deficiencies in the protection of subjects in clinical drug trials under China’s current laws and regulations; it emphasizes that investigators, as practitioners who have direct contact with subjects, play significant roles in protecting and safeguarding subjects’ rights and interests. The paper compares the status quo in China in this area to that of other countries and discusses ways China might enhance (...) the protection of rights and interests of trial subjects, such as enhancing the ethical awareness of investigators through training, improving laws and regulations, and strengthening the communication between investigators and ethics committees. (shrink)

We applaud Ray and Cooper (2024) for emphasizing environmental health as a bioethics issue. As a team of interdisciplinary pediatric researchers and providers who are part of an institutional clima...

Previous studies have identified the critical role of the left fusiform cortex in visual word form processing, learning, and memory. However, this so-called visual word form area's other functions are not clear. In this study, we used fMRI and the subsequent memory paradigm to examine whether the putative VWFA was involved in the processing and successful memory encoding of faces as well as words. Twenty-two native Chinese speakers were recruited to memorize the visual forms of faces and Chinese words. Episodic (...) memory for the studied material was tested 3. h after the scan with a recognition test. The fusiform face area and the VWFA were functionally defined using separate localizer tasks. We found that, both within and across subjects, stronger activity in the VWFA was associated with better recognition memory of both words and faces. Furthermore, activation in the VWFA did not differ significantly during the encoding of faces and words. Our results revealed the important role of the so-called VWFA in face processing and memory and supported the view that the left mid-fusiform cortex plays a general role in the successful processing and memory of different types of visual objects. © 2010 Elsevier Inc. (shrink)

If F ⊆ NN is an analytic family of pairwise eventually different functions then the following strong maximality condition fails: For any countable H ⊆ NN. no member of which is covered by finitely many functions from F, there is f ∈ F such that for all h ∈ H there are infinitely many integers k such that f(k) = h(k). However if V = L then there exists a coanalytic family of pairwise eventually different functions satisfying this strong maximality (...) condition. (shrink)

What is the nature of truth? This question has been answered by philosophers in quite different ways, while F. H. Bradley asserts that truths have degrees and that no proposition can be stated to be simply true or false. In this paper, I briefly illustrate what he calls the doctrine of degrees of truth and try to address the problems it entails. I first explain what he means by truth and error/falsehood (he does not make a clear distinction between the (...) two terms); then, I concentrate on his criticisms of three theories of truth, followed by a discussion of his own identity theory of truth. I will be focusing on his doctrine of the degrees of truth and highlight its difficulties. I show that his theory faces some insurmountable difficulties, and it should be motivated by a particular form of monism that he insisted on, saying existence monism. (shrink)

Originally published in 1915, this book presents the content of four lectures delivered by the author at the University of Cambridge from 1914 to 1915, as part of the Hulsean Lectures series. The text discusses the abiding value of Pascal and deals with misconceptions regarding the nature of his work and character. Detailed notes and an authorial preface are also provided. This book will be of value to anyone with an interest in Pascal and his influence on early twentieth-century thought.

Without intervention, a small preponderance of female over male infants will be born, and female children will have a slightly higher chance of living to maturity. Thereafter, the female population will decline comparatively sharply in consequence of death in childbirth. Historical evidence indicates that throughout the recorded history of Britain, there was a relative scarcity of women, and men dominated social structures. This situation was only reversed in the early decades of the 20th century, a time when three generations of (...) young men had gone, in …. (shrink)

Guidelines for a model bride in Islam based on Islamic teachings; includes stories of six exemplary Muslim wives during Prophet Muhammad's time.

The passage here discussed, VIII. 6. 33, occurs in one of the lacunas, and we are thus deprived of the help of the great mutilated MSS., and have to fall back upon A. and G. (the scribe who in the eleventh century filled up the lacunas in the mutilated Bambergensis. In § 31 Quintilian, in the course of his treatment of tropes, has reached onomatopoeia, and in § 32 that subdivision of the last-named, or perhaps we should say the kindred (...) subject, which he calls πεποιημένα This was as follows: uix ilia quae πεποιημένα uocant quae ex uocibus in usum receptis quocumque modo declinantur, nobis permittimus, qualia sunt ‘sullaturit’ et ‘proscripturit,’ atque ‘laureati postes’ pro illo ‘lauru coronati’ ex eadem fictione sunt. Sed hoc feliciter eualuit. (shrink)

Cognition or higher brain activity is sometimes seen as a phenomenon greater than the sum of its parts. This viewpoint however is largely dependent on the state of the art of experimental techniques that endeavor to characterize morphology and its association to function. Retinal ganglion cells are readily accessible for this work and we discuss recent advances in computational techniques in identifying novel parameters that describe structural attributes possibly associated with specific function. These parameters are based on calculating wavelet gradients (...) from cell images followed by the extraction of meaningful measures including 2nd wavelet moment, entropy of orientation, and curvature. For the three cell types analyzed, the mean 2nd wavelet moment, which relates to the field of influence of the dendritic-tree segments was significantly different. cells had the highest mean 2nd wavelet moment, followed by the and cells (134 ± 22, 93 ± 19 and 63 ± 12, respectively). There was no significant difference between cells for entropy of orientation, indicating no class with a preferential orientation of their dendritic tree. Curvature provided similar results to the 2nd wavelet moment with cells having the highest curvature followed by and the cells (mean ± SD: 161 ± 15; 134 ± 22; 121 ± 15). Our feature space analysis also indicated a difference between these cell types. No difference was found between the and cell types and their physiological counterparts the Y and X cells based on wavelet analysis. Both the X and Y cells can be divided into two subtypes, the ON- and OFF-center cells based on the stratification level of the dendritic tree within the retina. Using 2nd wavelet moment, a difference in their morphological attributes, not reported previously, was noted for these subtypes. The 2nd wavelet moment and curvature are further discussed with respect to explaining regularity of spacing and coverage associated with retinal ganglion cell mosaics. (shrink)